Banning Tobacco Price Promotions, Smoking Related Beliefs...

Banning tobacco price promotions, smoking-related beliefs and behavior: Findings from the International Tobacco Control four-country cohort survey Abstract Purpose: We examined how prohibiting tobacco price promotion at the national level influenced smoking-related beliefs and behaviors. Method: We used data from the International Tobacco Control Policy Evaluation project four-country cohort. Smokers and recent quitters at wave 8 (N = 4,114) were included in multivariate logistic regression models to examine associations between exposure to price promotions at waves 7 and 8 (conducted in 2008-2009 and 2010) on smoking-related beliefs and behavior at wave 8, stratified by whether the countries allow (United States, Australia) or ban†¦show more content†¦Conclusion: Differential associations emerged between exposure to price promotions and smoking-related beliefs across ban- vs. no-ban countries. Frequent exposure to promotions repeatedly predicted smoking-related beliefs and subsequent smoking behaviors in no-ban countries. Adopting price-promotion bans could eliminate effects of tobacco price promotions on smoking. Key words: International health, Smoking behavior, Smoking-related beliefs, Tobacco-control policy, Tobacco promotions Introduction Tobacco use remains the leading cause of preventable deaths and illnesses. Worldwide, the burden of tobacco exceeds six million deaths and half a trillion in economic loss annually. Tobacco-related deaths are projected to reach 7.4 to 9.7 million by 2030. To combat tobacco-use epidemic, the World Health Organization (WHO) enacted a Framework Convention on Tobacco Control (FCTC) that included six tobacco-control strategies to guard against both demand and supply arms of tobacco use. Abbreviated as â€Å"mpower,† these strategies include monitoring tobacco use and prevention strategies; protection against tobacco smoke; offering cessation aid; warnings against tobacco-related risks; enforcing advertising, promotional, and sponsorship bans; and raising taxation on tobacco products. , Advertising, promotional, and sponsorship ban remains the least adopted â€Å"mpower† strategy. Only 24 countries (covering a mere 10% of the world’s

Genderless Identity Does More Harm than Good - 1137 Words

When I finished reading the story of little Storm, in that instant, I felt deeply sorry for Storm, a child who would have grown up normally like everyone else around him/her, everyone else except for his/her two brothers. However, a decision was made by Storm’s parents to break the convention of identifying children by gender, and as a result the chance for Storm to be raised like others. Storm’s parents, Witterick and Stocker are indeed doing something wrong. Their extreme and unusual parenting decision would make Storm a lifelong victim of prejudice. According to Storm’s parents, they want to love their children for who they are, not what genitals they have; they want to be supportive of the individuality of their children†¦show more content†¦Recalling my memory from kindergarten, there was a little boy in my class who always wanted to play with the girls, while everyone else was only playing with others who shared the same sex. Consequently, he was a lienated from both sexes. He eventually quit school because he was later diagnosed as having melancholia, which was the result of being isolated and having to stay alone. As well there are other studies of the effects of isolation. According to an investigation in 1986, 5000 per 100,000 of the U.S. prisoners committed suicide as a result of less to no social activities and isolation. At several mid-Atlantic universities, a study investigated 1000 students. Surprisingly, 12 percent of them admitted that they had thought about committing suicide, and more than half of the 12 percent claimed that the reason for their suicidal thoughts was simply due to the feeling of being unloved or isolated by others. Thus, it is reasonable to conclude that alienation for Storm would cause serious consequences if Storm were to be raised gender-free. Moreover, Storm’s parents practice unschooling, in which they believe that learning should be curiosity driven. This could cause Storm to be compl etely ignorant and incompetent in the end since the useful knowledge in textbooks tends not to interest children and can not be easily discovered in our daily lives. For instance, if Newton’s Law of physics were never written in textbooks, it would beShow MoreRelatedGenderless Identity Does More Harm than Good989 Words   |  4 Pagesthey are realistic about the society they live in. Whereas Storm’s parents are not only thinking, also acting as idealists through their action of raising a genderless baby in this imperfect world. In other words, their idealism has motivated them to rear Storm free of gender identities. However, life is a much more complicated topic than what an idealist is willing to understand and seek answers for. As a result, idealists such as Storm’s parents are often not taking the scientific actualitiesRead MoreGenderless: Sex and Children2044 Words   |  9 PagesWeek 4: Interview Paper Much like the outburst that same-sex marriage caused, we are now seeing the advent of arguments for genderless parenting; the idea that all a child needs is love and its irrelevant whether the loving persons are male or female. Now we have genderless kids. Kathy Witterick and David Stocker, the parents of Jazz (5), Kio (2) and four-month-old Baby Storm want to rear and love each of their children, not as their daughter or son, not as a girl or a boy, but as just theirRead MoreUnisex And The Utilitarian Ethical Dilemma Essay1950 Words   |  8 Pagesâ€Å"boy† means â€Å"insensitive jock† and â€Å"girl† means â€Å"submissive prima donna†. My kids have known since birth that gender is about identity, and that should they ever decide that the labels â€Å"boy† or â€Å"girl† don’t fit them, I’ll gladly change the names and pronouns I use when I speak about them’. Juniper is just one example of the many parents who believ e unisex is right or more morally preferable over gender specification, which is wrong, because of the negative connotations associated with that genderRead MoreGender Roles Research Paper1896 Words   |  8 PagesIs it a Boy or a Girl? When a child is born, it does not know anything about the world. As it gets older, the child learns morals and values from the people around it. One concept children learn is the role of gender in their lives. Young boys and girls are given different messages about what they are and are not supposed do in social situations, causing them to act and dress differently from one another. Gender is not something tangible that happens; it is something perceived by American societyRead MoreGender Leadership And Womens Leadership Styles5681 Words   |  23 Pagesonly making up twenty-one percent of leadership. Gender roles in leadership are constructed and reinforced with power being connected to the male leaders. While there is a lot of research on female leaders and how their leadership styles are different than their male counterparts there in not much research out there about authentic female leaders in nonprofits. This qualitative study will address the question how women and men n onprofit administrators demonstrates or exhibits the phenomena of authenticityRead MoreArab Culture - Essay6842 Words   |  28 Pagesprovide insight into a culture, but the accuracy and usefulness will depend on the context and specific circumstances. WHERE IS THE ARAB WORLD? †¢ The Arab world stretches from Morocco across Northern Africa to the Persian Gulf. The Arab world is more or less equal to the area known as the Middle East and North Africa (MENA). Although this excludes Somalia, Djibouti, and the Comoros Islands which are part of the Arab world. †¢ It can also be defined as those countries where Arabic is the dominantRead MoreLogical Reasoning189930 Words   |  760 Pagesiv Praise Comments on the earlier 1993 edition, published by Wadsworth Publishing Company, which is owned by Cengage Learning: There is a great deal of coherence. The chapters build on one another. The organization is sound and the author does a superior job of presenting the structure of arguments. David M. Adams, California State Polytechnic University These examples work quite well. Their diversity, literacy, ethnic sensitivity, and relevancy should attract readers. Stanley

Cause For Violent Protest Essay Example For Students

Cause For Violent Protest Essay Every person, everywhere, with no exceptions has experienced fear. Fear, to be afraid, has hit us all, whether it was fear of failing, or fear for your own personal safety. Fear is what keeps us on our alert edge. It kept you from jumping off the high dive when you were a child for fear you would get injured, and it kept you up late studying for fear of failing. It is the realization of consequences in the immediate or distant future. There are many forms of fear and we benefit from all of them. It never makes you do anything you do not want to do, and gets the consequences going through your head. Fear of failure in our classroom makes us work harder, and fear of dying on the beaches of Normandy made soldiers run that much faster. Fear is what keeps us on our toes. I know it changed my life tremendously on one occasion, and saved my life on another. Fear of failing English 1301 has me glued too my chair when all of my friends are mountain biking. At the age of seventeen, I was more concerned about having a good time then worrying about school. The result of this of course, was my dropping out of school. It took me only one day to realize what I had done. What was a seventeen-year-old drop out going to do? I sank into a major depression when I realized the severity of what I had done was. The first concern for my future arose, and the fear of it. I was on a nowhere road with no exits unless I did something drastic to change myself. One week later, fear of failure had me on a plane with a destination of Fort Benning, Georgia. It had driven me to enlist in the Army. Fear for my own personal safety saved my life one windy day in the Mojave Desert. My squad was sent to desert warfare school in Fort Irwin. The Battalion Commander decided it would be necessary to insert my team by means of parachute for reconnaissance on enemy movement. When the time came for me to jump out of the C-130 Hercules, I yelled, Rangers Lead the Way! and started my descent. I counted to three and only felt a small jerk. I looked up and saw the parachute had been fused closed. Without thinking I immediately pulled my reserve and pushed out its risers, only for it rocket up and wrap around my main, which stopped it from being completely, deployed. My natural reaction was to look down, the ground screamed toward me at an incredible rate, I did not want to die, and the fear of death shot throughout me. It was this fear that took over and started throwing off weight. I cut off my rucksack, my weapon, and my low bearing vest, then it steered me the best it could into a patch of bushes below me that turned out to be a tree. It took me two days to finally remember what I had done because I had done it so fast and without thinking. With the help of fear I cheated death that day, and only suffered two dislocated kneecaps, a twisted back, twisted neck, and broken sternum. Fear is not just an emotion, it is a tool as well. Dog owners use it when they post their Beware of Dog signs to ward off any thieves. In Desert Storm the Allied Forces dropped millions of flyers over Iraqi positions telling them how to surrender to the technologically advanced army that was approaching them. Needless to say, this method of widespread fear caused panic, resulting in success and saving thousands of lives. During the dark ages, churches were not made to be peaceful looking in appearance, but rather intimidating. Churches had gargoyles on all sides of them, showing people what would come for them if they deified Christianity. .uecb1f1dd48abc22c07eca4a74097ca13 , .uecb1f1dd48abc22c07eca4a74097ca13 .postImageUrl , .uecb1f1dd48abc22c07eca4a74097ca13 .centered-text-area { min-height: 80px; position: relative; } .uecb1f1dd48abc22c07eca4a74097ca13 , .uecb1f1dd48abc22c07eca4a74097ca13:hover , .uecb1f1dd48abc22c07eca4a74097ca13:visited , .uecb1f1dd48abc22c07eca4a74097ca13:active { border:0!important; } .uecb1f1dd48abc22c07eca4a74097ca13 .clearfix:after { content: ""; display: table; clear: both; } .uecb1f1dd48abc22c07eca4a74097ca13 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .uecb1f1dd48abc22c07eca4a74097ca13:active , .uecb1f1dd48abc22c07eca4a74097ca13:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .uecb1f1dd48abc22c07eca4a74097ca13 .centered-text-area { width: 100%; position: relative ; } .uecb1f1dd48abc22c07eca4a74097ca13 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .uecb1f1dd48abc22c07eca4a74097ca13 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .uecb1f1dd48abc22c07eca4a74097ca13 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .uecb1f1dd48abc22c07eca4a74097ca13:hover .ctaButton { background-color: #34495E!important; } .uecb1f1dd48abc22c07eca4a74097ca13 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .uecb1f1dd48abc22c07eca4a74097ca13 .uecb1f1dd48abc22c07eca4a74097ca13-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .uecb1f1dd48abc22c07eca4a74097ca13:after { content: ""; display: block; clear: both; } READ: Light And The Glory EssayUsing it as a tool such as in this case kept people fearful of Gods wrath. Fear, although annoying at times, is an emotion and a tool that helps us all. It helps us in decision-making and generally steers us in the right direction. Most people do despise this emotion, and will not attempt anything or take any chance voluntarily that would provoke this emotion. What is not realized is that this is another one of the many emotions that make us human, and experiencing them makes us who we are. It plays a major role in our everyday lives.

Smoke Disavantages Essay Example

Smoke Disavantages Essay Smoking causes illness and death, among other disadvantages. It is the most preventable lifestyle factor affecting human health. Smoking harms every organ in your body. Your heart, blood vessels, lungs and fertility are all negatively affected by smoking and the chemicals in cigarettes. Heart and Blood Vessel Health Smoking changes the structure of blood vessels. This can lead to the buildup of plaque that hardens and narrows the vessels, causing a disease called atherosclerosis. Atherosclerosis is a common cause of heart attacks and peripheral artery disease. Smoking increases your likelihood of developing high blood pressure. The carbon monoxide inhaled from cigarette smoke interferes with the way oxygen is carried by your blood to organs, including the heart, which links it to heart disease. Smoking also increases the incidence of blood clots, which can lead to strokes. Lung Function The lung is the main target of the smoke inhaled by cigarettes because it has direct contact with the chemicals. Smoking is the most common cause of chronic obstructive pulmonary disease, or COPD, which affects the function of the lungs and how they deliver oxygen into the body. COPD includes chronic bronchitis and emphysema and involves a change in the structure of your lung tissue and airways. If you have asthma, smoking can increase the frequency and severity of attacks. Smoking diminishes lung function, so you may experience shortness of breath even with little or no exertion. Effects on Fertility and Babies Smoking contributes to infertility and decreases the chance of conception whether you are a man or woman. Men who smoke are found to have a reduced total sperm count in addition to a decrease in the sperms ability to fertilize an egg. Smoking diminishes the capacity of an ovary to create eggs that are capable of healthy fertilization. If you are pregnant and a smoker, you increase the risk of a low-birth-weight or preterm baby. An estimated 20 to 30 percent of low-birth-weight babies and 14 percent of preterm births are attributed to smoking in pregnancy, according the U. S. Surgeon Generals report on women and smoking. There is a higher chance your baby will have asthma if you smoked during pregnancy. Even some full-term babies will have diminished lung function if you smoked while pregnant. We will write a custom essay sample on Smoke Disavantages specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Smoke Disavantages specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Smoke Disavantages specifically for you FOR ONLY $16.38 $13.9/page Hire Writer

Rear Window essays

Rear Window essays Watching movies is what I do best, but all this time I have never watched anything so thrilling, tense and amazingly significant as an Alfred Hitchcock movie. His greatest film..."Rear Window" is probably Alfred Hitchcocks most perfectly constructed film. It takes place during four days, from Wednesday to Saturday, and the events are filmed from the window of one apartment and mostly through the eyes of one person - the magazine photographer L.B. Jeffries (James Stewart), confined to a wheelchair with his leg in plaster. One of my goals is to describe to you what I understood and loved about this movie, because Sometimes you see or hear things that make a huge impact to where you think about it hours after it's over. This is the case with Rear Window. What is it that makes Rear Window such a great movie? Let me count the ways. First of all, is the obvious. Rear Window is by the greatest director who ever lived Alfred Hitchcock. He was a master of suspense without using profanity, gore, nudity, or even graphic violence. He scared us with only a camera and some lights. The suspense in the film is based on the unquestionable logic of terror. The terror is not in the scene projected on the screen, but in the minds of the audience. Hitchcock slowly awakens in the audience a stream of suspense, which he dams until the final cataractous release. Hitchcock planned his film so accurately that after it had been edited, only a few dozen meters of film remained on the cutting room floor. This shows how amazing he was in directing, and how well the editor did his job. He shows the murderer creeping up the stairs to Jeffs flat leaving the unfamiliar rear of the building into the audiences imagination and it is just the unfamiliar rear that maximizes the threat: at this stage the threat is not just the rather pathetic M r. Thorwald, but the complex unfamiliarity of the building itself. As for the knowledge of the door...

Meet Us #IRL At Content Marketing World This September 5-8, 2017! - CoSchedule Blog

Meet Us #IRL At Content Marketing World This September 5-8, 2017! Blog Will you be in Cleveland, Ohio, for Content Marketing World this September? Me, too. You read that right- will be at Content Marketing World this  September 4-8, 2017. So come meet us at our booth! And  you can even grab some super actionable education from our CEO and Co-Founder, Garrett Moon, who is leading a session at Content Marketing World. Its gonna be fun. And we wanna share that fun with you. So stay in the loop if youre going to be there, and get on this special email list right now.  Well use this list to keep you informed of  what were up to at Content Marketing World and in Cleveland. (function () { var e = document.createElement('script'); e.type = 'text/javascript'; e.async = true; e.src = ('https:' == document.location.protocol ? 'https' : 'http') + '://btn.createsend1.com/js/sb.min.js?v=3'; e.className = 'createsend-script'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(e, s); })(); If youre gonna be at Content Marketing World this fall its time for you to make a couple plans. Let me help you do just that. Attend Garretts Session = Going Beyond Content Marketing: Turning Traffic Into Leads You’re consistently hammering out content†¦ but no one’s buying. Content into a demand generation engine is a riddle every marketer has to solve. So how do you optimize your content to attract the right audience that will convert into the perfect customers for your business? The silver bullet exists. Attend Garretts session  to learn the secrets to turning traffic into leads and quadruple your content’s results through agile, startup-driven frameworks. Register to attend Garretts  session now on the official Content Marketing World website. Add this to your calendar now: Date: September 7, 2017 Time: 11:05-11:50 a.m. Location: Hope Ballroom A-C (Hilton Level 3) ^^I wouldnt miss Garretts session if I were you. ;) Connect  With Us At  The Booth At Content Marketing World Are you a marketing nerd? Have you considered using to organize all of your marketing projects in one place? Are you a current customer? If you answered, Yes, Nathan! to any of those questions, have I got a deal for you! Visit the booth to visit  with a bunch of team members. Youll get: Answers to your  nerdiest marketing questions. More information on and how you can get your marketing team extremely organized. Some cool swag like stickers, autographed books from our pal, Jay Baer, and a whole lot more. Ill be there, too. So Im looking forward to meeting all of you IRL! Heres where were going to be: ^^^ So you should be there, too. :D Add Two Things To Your Must-Do List At Content Marketing World Alright: Youve got two things to do: Register to attend Garretts session on turning your traffic into leads. Youll also want to add this to your calendar. (Im pretty big on scheduling, if you havent noticed.) ;) Make a note to meet us at the booth on September 5, 6,  7, or 8 to ask your marketing questions and learn how will help you organize everything. One last thing: Subscribe to this special email list so we can keep in touch with you! This list is only for the goings-on at Content Marketing World, so subscribe NOW: (function () { var e = document.createElement('script'); e.type = 'text/javascript'; e.async = true; e.src = ('https:' == document.location.protocol ? 'https' : 'http') + '://btn.createsend1.com/js/sb.min.js?v=3'; e.className = 'createsend-script'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(e, s); })(); Were excited to meet you!

Gender, Crime & Justice ( social policy studies) Essay

Gender, Crime & Justice ( social policy studies) - Essay Example Or the court may dismiss the case and the trial will not begin. This is unethical and the case of rape ends even before it begins. Even in such modern societies of today, women are constantly being subjected to gender inequality and injustice. Gender injustice can be described as any kind of bias or discriminating behavior done on the origin of gender, be it male or female, just like discrimination is done on the grounds of race, religion, color or creed. However, the issue of gender injustice to women is given great importance by feminists around the world, presently, as compared to male gender injustice. Many laws and regulations have been produced to protect women’s rights from human rights abuse. Crime is defined as any act contrary to law, human or divine, an offence or breach of regulation, a wrong doing, and a sin that is punishable by law. In most cases a crime is a product of free-will, the choice of an individual or group who has weighed the consequences and then com mitted the act. Crime can also be the result of a mental deficiency, emotional disorder or due to cultural and biological factors. 44% of drug users are said to be involved in crime. International criminals generate almost $10 billion as foundation businesses of international criminal networks. ... The reasons that accounts for committing crimes like rape and juvenile delinquency are mainly opportunity, dare-devilry, and feelings of bravado, breakdown of values, greed, peer pressures, personal motives, easy access to guns, weak or extreme hold of religion and drug/alcohol addictions. It is observed that people who live with an inferiority complex are more likely to be criminals and also those who desire for power or authority, wanting to attract attention, enjoying risks, who desires revenge or have grown up in violent atmospheres. People who get brainwashed or have no fear of accountability or being caught are also likely to be criminals [Agha: 2006]. However, the rate of women committing crimes is also increasing since the last century. Women are generally thought to be of a kind, loving and gentle nature. They are usually not assumed to be associated with crimes. But the constant race and demand for gender equality, and new face of violent women being shown on television and movie screens has led to the recognition and acceptance of women committing crimes. The FBI’s Uniform Crime Report of 1996 showed that a surprising research that 93% of women were arrested for doing crime compared to only 43% of men arrested for being involved in crimes in the time span of last 10 years. These crimes included rape, prostitution and sexual assaults. Men were arrested more for murders, for which only a small number of women were responsible. Both men and women are responsible for the prevailing crime rate in a country and should be punished equally on same grounds and principles with no favoritism or biasness. Lately, a lot of evidences have been presented to proof the fact that more number of women is involved in crimes today rather than men.

An Investigation into the Factors that Impact on the Retention of Dissertation

An Investigation into the Factors that Impact on the Retention of Generation Y Workers in Nestle South Africa - Dissertation Example 89). Other terms have been used synonymously to pertain to the same group, such as â€Å"Millenials†, â€Å"Echo-Boomers†, or the â€Å"iGeneration†. These young individuals possess a set of common characteristics and expectations distinct from older generations who have preceded them. This generation can create considerable impact both as employees and consumers, meriting an investigation of the factors that influence their cognition, affect, and behaviours at work. The Nestle brand has continuously created an extensive range of products with superior quality, targeted towards consumers at a global scale. The multinational organisation, has been acknowledged internationally, owing to their research and development capabilities, geographic presence, and the premium that they place on their employees and their culture. Over 3,300 employees work for Nestle, 82% of whom are Black and 32% being females. Because of the organisation’s concern towards enhancing e mployee performance and well-being, Nestle has devised employee assistance programs that promote emotional and psychological support and financial stability, among others, towards maintaining employee wellness and effectively reducing employee turnover. Owing to the substantial influence of Generation Y employees on achieving the organisational bottomlines, the current research aims to ascertain the factors that influence their retention. ... Individuals who have grown up at different periods of time are likely to be characterized by a unique set of attitudes, values, beliefs, and expectations which exert a significant impact on their mindsets, behaviours, and their response to the culture of the workplace they belong to. As members of Generation Y enter employment, work forces have become more generationally diverse, being composed of four generations, spanning over 60 years- the Traditionalists, Baby Boomers, Generation X, and Generation Y (Glass, 2007, p. 98). Generation Y, which represents the latest generation to join the workforce, can be considered as the â€Å"most technically literate, educated, and ethnically diverse generation in history† (Eisner, 2005, p. 6). Gen Yers value personal development, achievement, and continual learning. There are inherent challenges in teaching and learning Generation Y employees in the contemporary workforce (Jonas-Dwyer and Pospisil, 2004). Differences exist among these ge nerations particularly as regards their preferred work culture, and such leanings are reflected in their preferred values, work styles and management (Eisner, 2005). As argued by Westerman and Yamamura (2007, p. 150), a profound understanding of work environment preferences, work motivation, and other work-related outcomes, is essential at strategizing for effective recruitment, training, retention and rewarding of the young generation. The current study thus further examines the factors that contribute to the motivation and retention of Gen Y employees in the South African context, specifically in the Nestle organisation. 1.3 The Research Problem There has been no systematic

Cognitive Development of an Infant and Toddler Essay Example for Free

Cognitive Development of an Infant and Toddler Essay Piaget based the sensorimotor stage on his observations of his own children The Circular Reaction: a. Circular reactions are the means by which infants explore the environment and build schemes by trying to repeat chance events caused by their own motor activity. b. These reactions are first centered on the infants own body. Subsequently, they change to manipulating objects and then to producing novel effects in the environment. Substage 1: Reflexive Schemes a. Piaget regarded newborn reflexes as the building blocks of sensorimotor intelligence. b. At first, babies suck, grasp, and look in much the same way, no matter what the circumstances. Substage 2: Primary Circular Reactions-The First Learned Adaptations a. Infants develop simple motor skills and change their behavior in response to environmental demands. b. The first circular reactions are primary in that they are oriented towards the infants own bodies and motivated by basic needs. Substage 3: Secondary Circular Reactions-Making Interesting Sights Last a. Circular reactions of this substage are secondary in that the infants repeat actions that affect the environment. b. Infants can imitate actions that they have practiced many times. Substage 4: Coordination of Secondary Circular Reaction a. Intentional, or goal directed, behavior is the combination of schemes to solve problems. b. Piaget regarded meansend action sequences as the first sign that babies appreciate physical causality. c. Object permanence is the understanding that objects continue to exist when they are out of sight; it is not yet complete in this substage. d. AB search errors are committed by infants in this substage. Infants 8- to 12-months-old only look for an object in hiding place A after the object is moved from A to hiding place B. Substage 5: Tertiary Circular Reactions-Discovering New Means through Active Experimentation a. Circular reactions in this substage are tertiary in that the infant repeats actions with variation-exploring the environment and bringing about new outcomes. b. Experimentation leads to a more advanced understanding of object permanence. Toddlers no longer make the AB search error. Substage 6: Mental Representation-Inventing New Means Through Mental Combinations a. mental representations are internal images of absent objects and past events. b. The toddler can now solve problems through symbolic means instead of trial-and-error. c. Representation allows deferred imitation-the ability to copy the behavior of models that are not immediately present. d. Functional play is motor activity with or without objects during the first year and a half in which sensorimotor schemes are practiced. e. At the end of the second year, representation permits toddlers to engage in make-believe play.

Faith Vs. Temptation :: essays research papers

Faith vs. Temptation Temptation, at one time or another, has touched all of our lives. What made us choose one path over the other? Was it your faith in God, your knowing of what was right and wrong, or was it the influences of the loved ones you not only surround yourself with, but the one you have trusted to lead down the straight and narrow. All of these questions come to light in Nathaniel Hawthorne’s Young Goodman Brown. Hawthorne’s tale is of a young, newly wedded man, and his internal struggle between faith and temptation. Set in Salem, at the times of the witch trials, Young Goodman Brown begins to question his own faith as the devil himself sheds new light on Brown’s strong beliefs. “With heaven above, and Faith below, I will yet stand firm against the Devil!';… Or will he? Young Goodman Brown prepares to leave on his lonely, life-changing journey, by first saying good bye to his wife of three months. Faith as his wife is called, for symbolic reasons I’m sure, fears for her husband and wishes him to stay. This good bye is Brown’s chance to choose faith over temptation. “Poor little faith, thought he, for his heart smote him. What a wretch am I to leave her on such an errand!'; Brown gives in to temptation. This won’t be the last time. Being scared and alone on his journey, Brown talking to himself says, “What if the devil himself should be at my elbow!'; A few more steps and Brown now has a companion; coincidence? I think not. “The only thing about him that could be fixed upon as remarkable as his staff, which bore the likeliness of a great black snake...like a living serpent."'; It was after this initial greeting and Brown noticing his companion’s walking stick that Brown once again was torn between his faith and the temptation of the errand he was on. Goodman Brown tries to convince himself he is doing wrong and turn back. “Having kept covenant by meeting thee here, it is my purpose now to return whence I came. I have scruples touching the matter thou wot’st of.'; The devil tempts Brown in to continuing. “Let us walk on, reasoning as we go; and if I convince thee not thou shalt turn back.'; Again Brown gives in to temptation. “Too far! Too far! Exclaimed the goodman, unconsciously resuming his walk.

Aaron Beck

Section 1 Abstract Biography Aaron T. Beck Aaron T. Beck (July 18, 1921) was born in Providence, Rhode Island USA, the youngest child of four siblings. Beck attended Brown University, graduating magna cum laude in 1942, then attended Yale Medical School, graduating with an M. D. in 1946. He is an American psychiatrist and a professor emeritus in the department of psychiatry at the University of Pennsylvania. Beck developed cognitive therapy in the early 1960s, he is widely regarded as the father of cognitive therapy,and his ioneering theories are widely used in the treatment of clinical depression. Beck also developed self-report measures of depression and anxiety including Beck Depression Inventory (BDI), Beck Hopelessness Scale, Beck Scale for Suicidal Ideation (BSS), Beck Anxiety Inventory (BAI), and Beck Youth Inventories. He is the President Emeritus of the Beck Inst and the Honorary President of the Academy of Cognitive Therapy, which certifies qualified cognitive therapists. B eck's daughter, Judith S. Beck, is also a researcher in the field of ognitive therapy and President of the Beck Institute. She is married with four children, Roy, Judy, Dan, and Alice. He has nine grandchildren. Section 2 Question #1 Beck developed cognitive therapy in the early 1960s. He had previously studied and practiced psychoanalysis. Beck designed and carried out a numberof experiments to test psychoanalytic concepts of depression. Fully expecting research would validate these fundamental precepts, he was surprised to find the opposite. This research led him to begin to look for other ways of conceptualizing depression.Working with depressed patients, he found that they experienced streams of negative thoughts that seemed to pop up spontaneously. He termed these cognitions â€Å"automatic thoughts,† and discovered that their content fell into three categories: negative ideas about themselves, the world and the future. Beck then developed self-report measures of depress ion and anxiety including Beck Depression Inventory(BDI), Beck Hopelessness Scale, Beck Scale for Suicidal Ideation (BSS), Beck Anxiety Inventory (BAI), and Beck Youth Inventories. Section 3 Question # 2I think Beck seen human beings as basically being good. Beck states that depressive cognition could be a result of traumatic experience or incapable of adapting coping skills. Depressive people have a negative perception or belief about themselves and their environment. According to Beck,†If beliefs do not change, there is no improvement. If beliefs change, symptoms change. † I think this means that your thoughts and beliefs affect your behavior, He believed that bad behavior is caused due to bad thinking, and that thinking is shaped by our beliefs.

Tort Law

In any given situation, it is evidently clear that the company should remain responsible and legally liable to their people or employe and among the consumers that patronize their product. Thus, should there be any accident and/or damages that badly harm these people in the course of exercising their duties, as employees and workers, the company could be held liable and sue to settle their legal obligations in shouldering the damages and lost of these people.As for the case of The Bug Plant located in Shady Town, USA, the employees and the vendor that have been attacked and robbed in the parking lot of the company could possibly file a law suit against the The Bug Plant under the legal offense of Negligence, as written in the Tort Law.Given the fact that the incidents of robbery against these people have happened within the premises of the company's grounds, wherein these people are working as the company's workers, both of the employees and the vendor could sue the company under the Tort Law, as it is evident that The Bug Plant has failed to ensure the safety and security of these people while staying and performing their duties and responsibilities for the company.More so, with the prior information that the Shady Town has been plagued with a recent crime wave, the case of Negligence could be filed against The Bug Plant, as the company failed to do the necessary adjustment to strengthen their company security and ensure the welfare of their people.Thus, The Bug Plant could be sued under the Tort Law, as they failed to exercise and meet the required standard of care in doing business. Lastly, The Bug Plant could use the notion that the incidents of robbery in the parking lot against the second shift employees have happened after their shift and/or beyond their official work hours, as the BUG's potential defense.On the other hand, The BUG Plant could also use the fact, as their defense, that the vendor who has been robbed, while waiting for the dock manager, is not their legal employee and that they do not have direct employment connection with this person and they should not be held liable for any damages. References Definition of Tort. (n. d. ). Retrieved June 12, 2009, from http://www. personal-injury-info. net/definition-of-tort. htm Product Liability. (n. d. ). Retrieved June 12, 2009, from http://www. personal-injury-info. net/product-liability. htm

How to Make Friends in College

How to Make Friends in College Lets be honest: making friends in college can be scary. If youre heading to college for the first time, chances are you only know a few people, if that. If youre at a school where you feel like you dont have any friends, it might seem like its too late to focus on making new ones. Fortunately, your time in college is like no other. It is forgiving and built for you to learn and explore, especially when it comes to making friends. Challenge Yourself Making friends in college is a challenge. Know that making friends at school is going to require a little effort on your part. While friendships can blossom naturally, it takes some energy to go out and meet your soon-to-be-friends for the first time. So challenge yourself to step outside of your comfort zone. Do some of the social activities during orientation week sound lame? Yup. But should you go to them anyway? Most definitely. After all, do you want to experience a little awkwardness (the event) for long-term benefits (meeting people), or do you want to experience a little comfort (staying in your room) in exchange for long-term disadvantages (meeting people who might turn into friends)? A little effort now can pay off quite a bit later when it comes to making friends in college. So challenge yourself to try something new, even if it sounds unusual for you or a bit scary at first. Know That Everyone in College is New If youre a first-year student, nearly everyone in your class is brand new. Which means that everyone is trying to meet people and make friends. Consequently, theres no reason to feel awkward or shy about chatting up strangers, joining a group in the quad, or outreaching to as many people as possible. It helps everyone! Additionally, even if youre in your third year in college, there are still new experiences for you. That statistics class you have to take for grad  school? Everyone in it is new to you, and vice versa. The people in your residence hall, apartment building, and the club are all-new, too. So reach out and talk to folks whenever you find yourself in a new situation; you never know where your new best friend is hiding. Know That Its Never Too Late to Start Over in College   One of the best things about college is that its designed to help you grow. Just because you were focused on figuring out what you wanted to major in during your first two years doesnt mean that you cant, for example, join a fraternity or sorority your junior year. If you didnt realize your love of reading and writing poetry until you took that rockin course last semester, know that its not too late to join the poetry club. People come in and out of social spheres and cliques all the time in college; its part of what makes college great. Seize those kinds of opportunities to meet new people whenever and wherever you can. Keep Trying Alright, so this year you wanted to make more friends. You joined a club or two, looked at joining a sorority/fraternity, but its now two months later and nothings clicking. Dont give up! Just because the things you tried didnt work out doesnt mean the next thing you try wont work, either. If nothing else, you figured out what you dont like at your school or in certain groups of people. All that means is that you owe it to yourself to keep trying. Get Out of Your Room If you feel like you dont have any friends, it can be tempting to just go to class, maybe go to work, and then head home. But being alone in your room is the worst possible way to make friends. You have 0% chance of interacting with new people. Challenge yourself a little bit to be around other people. Do your work in the campus coffee shop, library, or even out on the quad. Hang out in the student center. Write your paper in the computer lab instead of your room. Ask some students in your classes if they want to make a study group together. You dont have to be best friends right away, but you will end up helping each other with your homework while also getting some time to get to know each other. There are tons of ways to put yourself in situations where meeting people and making friends can happen organically- but being in your room all the time isnt one of them. Get Involved in Something You Care About Instead of making friends being your motivating factor, let your heart lead the way. Find a campus organization or club, or even one in your neighboring community, and see how you can get involved. Chances are, along with the good work youll be doing, youll find some people with similar values as you. And chances are at least one or two of those connections will turn into a friendship. Be Patient With Yourself Think back to when you were in high school and the friendships youve maintained from there. Your friendships probably changed and morphed from your first day of high school to your last. College is no different. Friendships come and go, people grow and change, and everyone adjusts along the way. If its taking you a little time to make friends in college, be patient with yourself. It doesnt mean you cant make friends; it just means you havent yet. The only way you will end up definitely not making friends in college is to stop trying. So as frustrating  as it may feel and as discouraged as you may be, be patient with yourself and keep trying. Your new friends are out there!

Beans and More Beans

Beans and More Beans Beans and More Beans Beans and More Beans By Maeve Maddox Considering the flurry of comments triggered by my inclusion of a bean idiom in a recent post, I decided to give the humble bean a post of its own. The noun bean is Germanic in origin. August Fick (1833-1916) German comparative linguist, suggested that bean was cognate with faba, the Latin word for bean, but according to the OED, â€Å"phonetic considerations render this doubtful.† Originally, the word bean referred only to the broad bean (Faba vulgaris), but now it refers to any seed that resembles it. Human beings and beans have had a long relationship; Egyptians buried them with their dead, and Homer mentioned them in the Iliad. On the ancient Roman feast called the Lemuria (or Lumuralia), the pater familias (father of the family) got out of bed at midnight to walk around the house barefoot, throwing black beans over his shoulder. The rite was intended to exorcise any malevolent spirits that had accumulated in the household during the previous year. Pythagoras instructed his followers â€Å"not to love beans,† but he may have been warning them against meddling in politics, not forbidding them to eat beans; beans were used as markers in political elections. Artistotle equated the bean with venery (pursuit of sexual pleasure); to him, â€Å"abstaining from beans† meant â€Å"keeping the body chaste.† As common objects of daily life, beans found their way into literary and proverbial use. â€Å"Not worth a bean† came to mean worthless. Chaucer (1343-1400) uses the expression in â€Å"The Merchant’s Tale.† The hero of the tale is a knight who, after 60 years of bachelorhood, finally decides to marry: â€Å"For no other way of life,† he said, â€Å"is worth a bean.† A person who â€Å"does not have a bean† is poor indeed, although the bean in this expression may originate elsewhere than with the legume. A slang term for a sovereign or a guinea was bean. â€Å"Not to have a bean† meant â€Å"not to have a cent.† â€Å"Not to know beans about something† is to know nothing about it: Charles Faddis Does not Know Beans About Nuclear Energy â€Å"To spill the beans† is â€Å"to reveal a secret†: Drunk Whistleblower Spilled The Beans On Chemtrail Front Company For CIA The business world has a couple of bean expressions all its own. A â€Å"bean counter† is a contemptuous term applied to an accountant or other financial expert by people who feel that creativity is more valuable than mere record-keeping. A beanfeast or beanfest is an annual dinner given by an employer to his employees. The word bean is slang for head: â€Å"Im a bit short on brain myself; the old bean would appear to have been constructed more for ornament than for use, dont you know†Ã‚  Ã¢â‚¬â€œP. G. Wodehouse, My Man Jeeves Wodehouse and other British writers used â€Å"Old Bean† as a friendly term of address: â€Å"You don’t mind my asking, do you old bean?† â€Å"Use your bean† means â€Å"think!† The little cap called a beanie gets its name from this meaning of bean, as does the baseball term bean ball, â€Å"a ball thrown at a batter’s head.† This application of bean has also given us a verb bean, â€Å"to hit someone on the head.† A beanery is a cheap restaurant, presumably because the meals are heavy on beans. The American city of Bostonfamous for its baked beansis often referred to as â€Å"Bean Town.† The expression that inspired this post is â€Å"full of beans,† meaning â€Å"full of energy and high spirits†: [In winter I try] to rise and shine, full of beans, every day.   [Reba] seems fresh, fit and full of beans, projecting herself the way I’m told she always does When I defined â€Å"full of beans† as â€Å"full of energy and high spirits,† several readers informed me of another meaning: â€Å"full of baloney† (or what bologna becomes once it is digested.) â€Å"Full of beans† in the sense of â€Å"energetic† probably originated as stable slang. Bean-fed horses were observed to be in good condition and lively, as in these examples from the OED: 1870  Ã‚   Daily News 27 July 5  Ã‚   The horses [] looked fresh and beany. 1843  R. S. Surtees Handley Cross II. vii. 199  Ã‚   [Hounds, horses], and men, are in a glorious state of excitement! Full o beans and benevolence! Another 19th century use of â€Å"full of beans† noted as stable slang was applied to a person â€Å"whom sudden prosperity had made offensive and conceited.† I suppose that such a stuck-up person could be seen as â€Å"full of beans† in the sense of being â€Å"full of it.† Apparently both meanings are current, so don’t be surprised if you get a puzzled look if your meaning doesn’t match that of your listener. I’ll end with what is probably the best-known bean quotation in popular culture, Rick’s farewell to Ilsa in the movie Casablanca: Ilsa, I’m no good at being noble, but it doesn’t take much to see that the problems of three little people don’t amount to a hill of beans in this crazy world. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Expressions category, check our popular posts, or choose a related post below:Creative Writing 1017 Patterns of Sentence StructureHyphenation in Compound Nouns

Praxis of Pastoral Counseling Essay Example | Topics and Well Written Essays - 1000 words

Praxis of Pastoral Counseling - Essay Example As the essay outlines  since individuals today are faced with major problems concerning their social status, it could not be avoided that most issues that are presented to the counselors are involved with the inability of the individuals to gain the things that they ought to gain from the society. Aside from this, the fact that the thoughts of human philosophy are not in full accordance with the principles of the Bible, Christian Counseling faces so much issues as to how it is considered effective by individuals who are expecting counseling assistance.  This paper discusses that the crisis in counseling procedures especially that of the Christian-based procedure of counseling is mainly focused on the practicality and the effectiveness of the said process of counseling. The fact that Christian Counseling is based upon the principles of the Holy Scriptures, and that not so many people believe in the power of the Bible nowadays, questions the power of the word of God to actually aid e individuals with their personal issues and thus be able to solve the said problems in a  Ã‚   more practical and effective procedure. However, through the effective application of the principles of the Bible in actual counseling procedures, these questions could be answered and thus prove the fact that the counsel from God’s word is indeed effective and useful for every believer of the truth.  Counselors are expected to have a special concern on how others are feeling. The emotional display of the situation that they are currently dealing with should be immediately noticed by the counselors. This ability is not at all innate.... g is to have faith that these particular guidance assistances could lead to the betterment of the situations that each individual deals with at present. While God is not at this time performing such direct miracles, Christians today find that if they 'do not waver in a lack of faith,' they, too, can enjoy success when they apply God's direction. Said Jesus: "All things can be to one if one has faith."(Mark 9:23) Since individuals today are faced with major problems concerning their social status, it could not be avoided that most issues that are presented to the counselors are involved with the inability of the individuals to gain the things that they ought to gain from the society (Culbertson, 2000, 10). Aside from this, the fact that the thoughts of human philosophy are not in full accordance with the principles of the Bible, Christian Counseling faces so much issues as to how it is considered effective by individuals who are expecting counseling assistance. (Culbertson, 2000, 262) The crisis in counseling procedures especially that of the Christian-based procedure of counseling is mainly focused on the practicality and the effectiveness of the said process of counseling. The fact that Christian Counseling is based upon the principles of the Holy Scriptures, and that not so many people believe in the power of the Bible nowadays, questions the power of the word of God to actually aide individuals with their personal issues and thus be able to solve the said problems in a more practical and effective procedure. However, through the effective application of the principles of the Bible in actual counseling procedures, these questions could be answered and thus prove the fact that the counsel from God's word is indeed effective and useful for every believer of the

Middle ages Essay Example | Topics and Well Written Essays - 500 words

Middle ages - Essay Example These revolutions in art were very significant because people would display their messages through their paintings. Renaissance architecture was very elegant and domed cathedrals like Saint Peter’s Basilica in Rome and Brunelleschis Cathedral in Florence were also very beautifully designed. The impact of Renaissance was very strong on Netherlands, France and England. It focused more on Science, Mathematics and Christianity. The Protestant Reformation was started by Martin Luther who remodeled the religious and political map of Europe. These reformers promoted education especially in Calvinist areas therefore the role of the Catholic Church was truncated. The Thirty Years War was also fought during this period between Spain and the Roman Empire over religious and nationalist issues. This upset the balance of the political power though there was a slight change in the social life as women’s role was improved. The Europeans were more interested in material wealth. There was an influx of gold and silver from Latin America that grew as colonization advanced. This change also hurt many others which resulted in the rise of proletariat who did not have anything except for their skills. Persecution began in this period which created hatred and fear in the hearts of the poor people. The Scientific Revolution spread rapidly transforming all the areas of Europe. Copernicus’ discovery of the heliocentric theory also brought about a great influence on scientific studies. His work was carried on by Kepler’s planetary observations and Galileo’s research. According to a famous scientist, John Locke, everything could be known with the use of reason through the sense. By 1750, political forms crystallized with few developments like that in Prussia. Dynamism, improvement in agriculture and religious tolerance could be seen under the leadership of Frederick the Great. Colonization was the cause of the increase in consumer demand for imported products. Agriculture was

Comparison-contrast essay Example | Topics and Well Written Essays - 500 words

Comparison-contrast - Essay Example In his article, Staffo presents an insightful discussion about interscholastic athletics. Although he acknowledges that interscholastic athletics is a good initiative that can positively contribute to the life of students, he says that it has not been used to instill educational values in learners as it ought to be. According to his research, the goals f scholastic athletics are no longer important to the school administration, teachers and students. Today, scholastic athletics has become a tool for propagating violence, unhealthy competition and encouragement of the domination of teachers over the student body. Similar sentiments are echoed by Pietrofesa and Rosen who traces the development of violence and criminal activities in athletics amongst the professional athletes, high school and college students. The other similarity in the articles is that they both give recommendations on how violence and other criminal activities in athletics can be resolved. To Staffo, the best thing to do is to stop perceiving scholastic athletics as a tool for competition. Being that students are encouraged to participate in athletics so as to defeat their opponent makes them grow up as bad citizens who can do anything at whatever cost to out do their opponents. Besides, both the scholars argue that it is upon the physical educators and coaches to ensure that they provide the necessary counseling skills on their athletes. Better still, team managers should offer periodical lectures on athletes so as to teach them on the benefits of refraining from violence and any other form of violence that can derail them from continuing with their athletics activities. However, despite these similarities, the articles have lots of differences. First, while Interscholastic Sports Msdirected? Misguided? Misnomer? is mainly concerned about high school athletics, Strategies for reducing criminal violence among

Investigating Alykl Hydoxylation in P450-can Using EVB

Investigating Alykl Hydoxylation in P450-can Using EVB Shen Ye Abstract Cytochrome P450s are a superfamily of haemoproteins1-3 which catalyse the oxidation of organic molecules4. One P450 enzyme studied for its hydroxylation mechanism is P450cam (CYP101) from the Pseudomonas putida bacteria, whose crystal structure (1DZ9) was solved by Schlichting et al.5. The active form of P450cam contains an oxyferryl species known as compound I(CPDI), where the iron has a formal oxidation state of Fe(V) 6, 7 in the plane of a porphyrin ring with a protruding oxygen atom. This oxygen atom is a tremendously potent oxidising agent and can readily abstract a hydrogen of a C-H bond from non-activated hydrocarbons with potentially high regioselectivity[REF]. Acknowledgements The author would like to thank: Patrick von Glehn Dr Richard Lonsdale Professor Adrian Mulholland Professor Jeremy Harvey Professor Neil Allan Table of Contents Abstract Acknowledgements Table of Contents Part I – Literature Review An introduction to haem oxygenases Cytochrome P450 enzymes P450 catalytic cycle P450cam An introduction to CHARMM and EVB Part II Methodology Part I – Literature Review An introduction to haem oxygenases After hydrogen and helium, oxygen is the third most abundant chemical element in the universe8 and makes up 20.9% of Earth’s atmosphere9. Oxygen accounts for 65% of the mass in humans8 as it is found in all biological systems including carbohydrates, proteins, lipids and water. Oxygen occurs in the atmosphere as dioxygen, with a triple ground state where the two unpaired electrons are occupying two degenerate molecular orbitals10. This makes incorporating atmospheric oxygen into organic molecules (predominantly singlet species) extremely difficult as it would be a spin forbidden process. Haem oxygenases are enzymes containing a prosthetic haem cofactor, an iron atom held by a porphyrin ring. Haem B is the most common prosthetic haem group, consisting of a protoporphyrin IX ring bound to the iron. It is most commonly found in the human body inside haemoglobin and myoglobin11, playing a major role when it comes to binding atmospheric dioxygen. There are two groups of haem oxygenases, monooxygenases and dioxygenases, one reacts using a single oxygen atom and the other using both oxygen atoms. The haem B cofactor and the apoenzyme are synthesised separately in different parts of a cell and they are connected via ligation to the iron atom on the proximal face12. The protoporphyrin ring is a tetrapyrrole macrocycle synthesised from basic biological precursors including succinyl CoA and the most basic amino acid, glycine13. Ferrochelatase coordinates the iron atom to the protoporphyrin, producing haem B14. In cytochrome P450 enzyme the iron is ligated to a proximal cysteine residue via the sulphur atom15, however in some other oxygenases and other haemoproteins such as haemoglobin and myoglobin the iron is coordinated to a proximal histidine residue16. In monooxygenases one of the dioxygen atoms is converted to H2O and the other is commonly inserted into an aliphatic position of the substrate, producing a hydroxyl group by oxidation of reducing agents such as NADH and NAD(P)H17, 18. The most studied haem-containing monooxygenases are the superfamily of cytochrome P450 enzymes due to their large diversity and versatility19, 20. Cytochrome P450 enzymes Cytochrome P450 enzymes (CYP) were first discovered by Axelrod21 and Brodie et al.22 in 1955 when they observed the oxidation of xenobiotic compounds in the endoplasmic reticulum of the liver, but the enzymes responsible were still unknown until 1962. Klingenberg23 and Garfinkel24 found a carbon monoxide binding pigment in the rat and pig livers, respectively, which had an absorption maximum at 450 nm. The CO molecule was bound to the centre of the haem and its 450 nm absorption maximum25 is prevalent in all CYPs26-28, an electron spin resonance spectrum identified this enzyme was a low spin haemoprotein29. This 450 nm Soret peak is the origin of the name P450. The superfamily of CYPs contain over a thousand haem monooxygenases30 and are present in nearly all living organisms and even viruses, a well-known exception is Escherichia coli4, 19 which is widely used to investigate CYPs by sequence insertion into plasmids and allow the E. coli to express the genes31, 32. CYPs typically con tain approximately 500 amino acids, the cysteine residue which ligates to the haem group is located near the carboxy-terminus and the amino-terminus region of CYPs are rich in hydrophobic residues and is believed to be responsible for binding the enzymes to the lipid bilayers of cells33. CYPs in mammals are a crucial part of catalysing the metabolism of organic compounds and the biosynthesis of steroid hormones34, such as oestrogen and testosterone, and are able to perform hydroxylation, epoxidations and other oxidation reactions at physiological temperatures35 extremely selectively. Such reactions when performed uncatalysed tend to require extremely high temperatures5. CYPs are tremendously versatile, they’re able to catalyse a wide range of foreign hydrophobic compounds, which helps to protect the organism if they have ingested potentially harmful substances including toxins and carcinogens36. This ability is often called â€Å"xenobiotic metabolism†37. There is a system for the nomenclature of P450 enzymes, which is â€Å"CYP† followed by a number, a latter and another number, e.g. CYP2J2. The first number relates to the family of the CYP, where all the CYPs in the family share a sequence identity of 40% or greater. The letter afterwards corresponds to the subfamily, where the CYPs in the subfamily share a sequence identity of 55% of greater. The final number is a label where all CYPs with this label share a sequence identity of 97% or greater38. CYPs with the same label are known as isoforms. Humans have 57 different CYP isoforms divided into 18 families and 42 subfamilies34. Most of the isoforms are found on membranes, including the inner membrane of mitochondria, the endoplasmic reticulum and the cell membrane. They all differ in roles but the processes they all catalyse are similar and a few are crucial for catalysing more than once process. For example CYP 17A1 is located in the endoplasmic reticulum and is shown to be both a hydrolase and lyase, a key enzyme in the biosynthetic pathway of steroids including oestrogens and progestins39. The most researched area of CYPs is the drug metabolising CYPs in the human hepatic system such as 3A440, 2C941, 2D642, 2E143, 1A2 and 2C1944. These CYPs are responsible for the xenobiotic metabolism against infested foreign compounds, breaking them down into more readily soluble products to aid excretion through the urinary system45. For this reason, a good understanding of the metabolic pathway of organic molecules inside the body al lows drug development to invent new methods of bioactivation of inert but bioavailable forms of an active compound, where the ingested compound is inactive but gets metabolised into the active form inside the body. The versatility of CYPs can sometimes cause unexpected side-effects in metabolising pharmaceutical drugs, for example some bioactive compounds in grapefruit juice have been found to inhibit CYP catalysed metabolism of certain cardiovascular drugs, causing an increased blood concentration of the bioactive drug, thus leaking to a risk of overdose46, 47. P450cam P450cam was the first CYP to have its three-dimensional structure determined. It displays a high region- and stereoselectivity when catalysing the hydroxylation of camphor, only the exo-hydroxyl at C5 position is produced. Despite the extensive research into P450s, there are still certain details of the mechanism which are not fully understood. References 1.T.K. D. R. Nelson, D. J. Waxman, F. P. Guengerich, R. W. Estabrook, R. Feyereisen, F. J. Gonzales, M. J. Coon, I. C. Gunsalus, O. Gotoh, K. Okuda and D. W. Nebert DNA Cell Biol, 1993. 12(1): p. 1-51. 2.C. Loannides and D. Parke, Drug metabolism reviews, 1990. 22(1): p. 1-85. 3.A. Altun, S. Shaik, and W. Thiel, Journal of the American Chemical Society, 2007. 129(29): p. 8978-8987. 4.P. Danielson, Current drug metabolism, 2002. 3(6): p. 561-597. 5.I. Schlichting, J. Berendzen, K. Chu, A.M. Stock, S.A. Maves, D.E. Benson, R.M. Sweet, D. Ringe, G.A. Petsko, and S.G. Sligar, Science, 2000. 287(5458): p. 1615-1622. 6.D. Dolphin, A. Forman, D. Borg, J. Fajer, and R. Felton, Proceedings of the National Academy of Sciences, 1971. 68(3): p. 614-618. 7.J.E. Penner-Hahn, K. Smith Eble, T.J. McMurry, M. Renner, A.L. Balch, J.T. Groves, J.H. Dawson, and K.O. Hodgson, Journal of the American Chemical Society, 1986. 108(24): p. 7819-7825. 8.R. Chang, Chemistry. 9th Edition ed. 2007: McGraw-Hill. 9.A. Murphy, Plasma Chemistry and Plasma Processing, 1995. 15(2): p. 279-307. 10.T.F. Slater, Free radical mechanisms in tissue injury, in Cell Function and Disease. 1988, Springer. p. 209-218. 11.A.R. Fanelu, E. Antonini, and A. Caputo, Advances In Protein Chemistry, 1964. 19: p. 73. 12.H.S. Marver, D.P. Tschudy, M.G. Perlroth, and A. Collins, Science, 1966. 154(3748): p. 501-503. 13.F.J. Leeper, Natural Products Reports, 1983. 19: p. 1137-1161. 14.T. Yoon and J. Cowan, Journal of Biological Chemistry, 2004. 279(25): p. 25943-25946. 15.A.W. Munro, D.G. Leys, K.J. McLean, K.R. Marshall, T.W. Ost, S. Daff, C.S. Miles, S.K. Chapman, D.A. Lysek, and C.C. Moser, Trends in biochemical sciences, 2002. 27(5): p. 250-257. 16.D.F. Brook and P.J. Large, European Journal of Biochemistry, 1975. 55(3): p. 601-609. 17.M.H.M. Eppink, C. Bunthof, H.A. Schreuder, and W.J.H. van Berkel, FEBS Letters, 1999. 443(3): p. 251-255. 18.S. Harayama, M. Kok, and E.L. Neidle, Annual Review of Microbiology, 1992. 46(1): p. 565-601. 19.A. Sigel, H. Sigel, and R.K. Sigel, The ubiquitous roles of cytochrome P450 proteins: metal ions in life sciences. Vol. 10. 2007: John Wiley Sons. 20.P.R.O. De Montellano, Cytochrome P450: structure, mechanism, and biochemistry. 2005: Springer. 21.J. Axelrod, Journal of Pharmacology and Experimental Therapeutics, 1956. 117(3): p. 322-330. 22.B.B. Brodie, J. Axelrod, J.R. Cooper, L. Gaudette, B.N. La Du, C. Mitoma, and S. Udenfriend, Science, 1955. 121(3147): p. 603-604. 23.M. Klingenberg, Archives of biochemistry and biophysics, 1958. 75(2): p. 376-386. 24.D. Garfinkel, Archives of biochemistry and biophysics, 1958. 77(2): p. 493-509. 25.R.W. Estabrook, D.Y. Cooper, and O. Rosenthal, Biochemische Zeitschrift, 1962. 338: p. 741-755. 26.T. Omura and R. Sato, J. Biol. Chem., 1962. 237: p. 1375-1376. 27.T. Omura and R. Sato, J. Biol. Chem., 1964. 239: p. 2370-2378. 28.T. Omura and R. Sato, J. Biol. Chem., 1964. 239: p. 2379-2385. 29.Y. Hashimoto, T. Yamano, and H. Mason, Journal of Biological Chemistry, 1962. 237(12): p. PC3843-PC3844. 30.B. ÄŒreÃ… ¡nar and Ã…  . PetriÄ , Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2011. 1814(1): p. 29-35. 31.E.M.J. Gillam, Z.Y. Guo, and F.P. Guengerich, Archives of Biochemistry and Biophysics, 1994. 312(1): p. 59-66. 32.A. Parikh, E.M. Gillam, and F.P. Guengerich, Nature biotechnology, 1997. 15(8): p. 784-788. 33.J.A. Hasler, R. Estabrook, M. Murray, I. Pikuleva, M. Waterman, J. Capdevila, V. Holla, C. Helvig, J.R. Falck, and G. Farrell, Molecular Aspects of Medicine, 1999. 20(1): p. 1-137. 34.D.W. Nebert and D.W. Russell, The Lancet, 2002. 360(9340): p. 1155-1162. 35.D. Harris, G. Loew, and L. Waskell, Journal of Inorganic Biochemistry, 2001. 83(4): p. 309-318. 36.P. Anzenbacher and E. Anzenbacherova, Cellular and Molecular Life Sciences CMLS, 2001. 58(5-6): p. 737-747. 37.X. Ding and L.S. Kaminsky, Annual review of pharmacology and toxicology, 2003. 43(1): p. 149-173. 38.R. Lonsdale, Cytochrome P450 Reactivity and Specificity from QM/MM Modelling, 2009, School of Chemistry, University of Bristol. 39.R. Zuber, E. Anzenbacherova, and P. Anzenbacher, Journal of cellular and molecular medicine, 2002. 6(2): p. 189-198. 40.J.S. Markowitz, J.L. Donovan, C.L. DeVane, R.M. Taylor, Y. Ruan, J.-S. Wang, and K.D. Chavin, Jama, 2003. 290(11): p. 1500-1504. 41.J.O. Miners and D.J. Birkett, British journal of clinical pharmacology, 1998. 45(6): p. 525-538. 42.A. Gaedigk, M. Blum, R. Gaedigk, M. Eichelbaum, and U. Meyer, American journal of human genetics, 1991. 48(5): p. 943. 43.G. Blakey, J. Lockton, J. Perrett, P. Norwood, M. Russell, Z. Aherne, and J. Plume, British journal of clinical pharmacology, 2004. 57(2): p. 162-169. 44.V. Uttamsingh, C. Lu, G. Miwa, and L.-S. Gan, Drug metabolism and disposition, 2005. 33(11): p. 1723-1728. 45.J.F. Rogers, A.N. Nafziger, and J.S. Bertino Jr, The American journal of medicine, 2002. 113(9): p. 746-750. 46.D.G. Bailey and G.K. Dresser, American journal of cardiovascular drugs, 2004. 4(5): p. 281-297. 47.H. Hirashima, N. Uchida, I. Fukazawa, S. Ishigaki, E. Uchida, and H. Yasuhara, Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 2006. 37(3): p. 127-133.

The Great Gatsby :: essays research papers

The central theme is a comparison of the corrupting influence of wealth to the purity of a dream. Tom and Daisy Buchanan both lead purposeless lives that are filled with corruption through wealth, while Gatsby lives his life striving towards his dreams. They all either have no purpose in life to begin with or lose all purpose and values due the actions of another. All of the wealthy characters, including Gatsby, use people and things and then discard them as trash..   Ã‚  Ã‚  Ã‚  Ã‚  Tom is probably leads the most purposeless life out of the three with no career. He spends his day’s playing with polo ponies and race cars. He has one affair after another and treats his mistresses of these affairs as if they were only toys. When he realizes that Daisy if having an affair with Gatsby he becomes enraged and comes back to his wife. After Daisy kills Myrtle they fleet together, neither claiming any responsibility for her death. This all shows that Tom is leading a purposeless life with no long-term goals or dreams.   Ã‚  Ã‚  Ã‚  Ã‚  Daisy, who is born and marries to wealth, also has no real values or purpose in life. She spends her life floating from one social scene to the next with, with all things about her resembling her money. She treats everyone, including her daughter, as toys that she uses for her entertainment. She goes off and has an affair with Gatsby simply to relieve her boredom. Even with all the money and possessions Daisy has no thoughts of what she will do with her purposeless life.   Ã‚  Ã‚  Ã‚  Ã‚  Gatsby is the only one of the three who is not corrupted by his wealth. Although he has a large mansion, drives flashy cars, and gives extravagant parties, he has amassed none of it for himself. Everything he has achieved in life he has done to fulfill his dream, to prove to Daisy that he is worthy of her. When Daisy shatters his dreams by choosing Tom over him, Gatsby has no need for his possessions. Once he loses Daisy, Gatsby also begins going through life with no purpose.   Ã‚  Ã‚  Ã‚  Ã‚  All of the wealthy characters, including Gatsby, use people and things and then

Cultural Influences Essay

How does an individual’s cultural experience influence his or her personality? Explain why or why not. Provide examples. Every person that is born in any family, in any part of the world is subjected to an upbringing that is surrounded by different sets of values, ethics and morals. These values in turn form the basis of a culture. The important point to note is that these values are never the same; they differ from culture to culture. A culture defines a society, the society in turn defines its norms and those norms and principles influence a personality(Reynolds , 2006). A personality is something that one cannot inherit. But it has a lot of power to be influenced by the atmosphere it is placed in. The question that rises in minds is how? Well let’s just say its human nature to adopt something that a person faces again and again repeatedly. To prove this we can see the example that the oldest of norms and values survive the most in any culture and thus are found to be a vital part of every person’s personality especially if they are from the same culture. This is why we note that people who migrate to different societies have problems in adjusting to the new culture. This is because their own native culture is so much ingrained in their personalities that it is difficult to eliminate it and replace it with new morals of the new society. The best example can be that of students who migrate to foreign countries for education. If a student who has been brought up in an eastern culture of the sub-continent will definitely have problems in adjusting to the new western culture that he has switched to. This is because that person has been brought up in a society that teaches him values completely opposite to the values of the western society that he has migrated to. And the old values are deep-rooted in his personality. He is greatly influenced by them therefore it results in problems regarding an adjustment in the culture. References Book Reynolds. J. (2006). Celebrate Connections among Cultures. Lee and Low Books.

The Emperor’s Role in Meiji Japan

Japan is a society whose culture is steeped in the traditions and symbols of the past: Mt. Fuji, the tea ceremony, and the sacred objects of nature revered in Shintoism. Two of the most important traditions and symbols in Japan; the Emperor and Confucianism have endured through Shogunates, restorations of imperial rule, and up to present day. The leaders of the Meiji Restoration used these traditions to gain control over Japan and further their goals of modernization. The Meiji leaders used the symbolism of the Emperor to add legitimacy to their government, by claiming that they were ruling under the â€Å"Imperial Will. They also used Confucianism to maintain order and force the Japanese people to passively accept their rule. Japanese rulers historically have used the symbolism of the Imperial Institution to justify their rule. The symbolism of the Japanese Emperor is very powerful and is wrapped up in a mix of religion (Shintoism) and myths. According to Shintoism the current Emperor is the direct descendent of the Sun Goddess who formed the islands of Japan out of the Ocean in ancient times. Footnote1 According to these myths the Japanese Emperor unlike a King is a living descendent of the Gods and even today he is thought of as the High Priest of Shinto. Despite the powerful myths surrounding Japan's imperial institution the Emperor has enjoyed only figure head status from 1176 on. At some points during this time the Emperor was reduced to selling calligraphy on the streets of Kyoto to support the imperial household, but usually the Emperor received money based on the kindness of the Shogunate. Footnote2 But despite this obvious power imbalance even the Tokugawa Shogun was at least symbolically below the Emperor in status and he claimed to rule so he could carry out the Within this historical context the Meiji leaders realized hat they needed to harness the concept of the Imperial Will in order to govern effectively. In the years leading up to 1868 members of the Satsuma and Choshu clans were part of the imperialist opposition. This opposition claimed that the only way that Japan could survive the encroachment of the foreigners was to rally around the Emperor. Footnote4 The Imperialists, claimed that the Tokugawa Shogunate had lost its imperial mandate to carry out the Imperial Will because it had capitulated to Western powers by allowing them to open up Japan to trade. During this time the ideas of the imperialists ained increasing support among Japanese citizens and intellectuals who taught at newly established schools and wrote revisionist history books that claimed that historically the Emperor had been the ruler of Japan. Footnote5 The fact that the Tokugawa's policy of opening up Japan to the western world ran counter to the beliefs of the Emperor and was unpopular with the public made the Tokugawa vulnerable to attack from the imperialists. The imperialists pressed their attack both militarily and from within the Court of Kyoto. The great military regime of Edo which until recently had been all owerful was floundering not because of military weakness, or because the machinery of government had broken but instead because the Japanese public and the Shoguns supporters felt they had lost the The end of the Tokugawa regime shows the power of the symbolism and myths surrounding the imperial institution. The head of the Tokugawa clan died in 1867 and was replaced by the son of a lord who was a champion of Japanese historical studies and who agreed with the imperialists claims about restoring the Emperor. Footnote7 So in 1868 the new shogun handed over all his power to the Emperor in Kyoto. Shortly after handing over power to the Emperor, the Emperor Komeo died and was replaced by his son who became the Meiji Emperor. Footnote8 Because the Meiji Emperor was only 15 all the power of the new restored Emperor fell not in his hands but instead in the hands of his close advisors. These advisers such as Prince Saionji, Prince Konroe, and members of the Satsuma and Choshu clans who had been members of the imperialist movement eventually wound up involving into the Meiji Bureaucracy and Genro of the Meiji Era. Footnote9 Once in control of the government the Meiji Leaders and advisors to the Emperor reversed their policy of hostility to Foreigners. Footnote10 They did this because after Emperor Komeo (who was strongly opposed to contact with the west) died in 1867 the Meiji Emperor's advisors were no longer bound by his Imperial Will. Being anti-western also no longer served the purposes of the Meiji advisors. Originally it was a tool of the imperialist movement that was used to show that the Shogun was not acting out the Imperial Will. Now that the Shogun and Komeo Emperor were dead there was no longer a reason to The choice of the imperial thrown by the imperialists as a point for Japan to rally around could not have been more wise. Although the imperial institution had no real power it had universal appeal to the Japanese public. It was both a mythic and religious idea in their minds. Footnote11 It provided the Japanese in this time of chaos after coming in contact with foreigners a belief in stability (according to Japanese myth the imperial line is a unbroken lineage handed down since time immortal), and it provided a belief in the natural superiority of Japanese culture. Footnote12 The symbolism of the Emperor helped ensure the success of the restorationists because it undercut the legitimacy of the Shogunate's rule, and it trengthened the Meiji rulers who claimed to act for the Emperor. What is a great paradox about the Imperialist's claims to restore the power of the Emperor is that the Meiji rulers did not restore the Emperor to power except symbolically because he was both too young and his advisors to power hungry. Footnote13 By 1869 the relationship between the Emperor and his Meiji bureaucracy and the Emperor and the Tokugawa Shogun before the restoration were very similar. Both the Meiji Bureaucrats and the Shogun ruled under the authority of the Emperor but did not let the Emperor make any decisions. In Japan the Emperor reigned but did not rule. This was useful for the new Meiji bureaucrats, it kept the Emperor a mythic The traditions and symbols of Confucianism and the Imperial Institution were already deeply ingrained in the psyche of the Japanese but the new Meiji rulers through both an education system, and the structure of the Japanese government were able to effectively inculcate these traditions into a new generation of Japanese. The education system the Meiji Oligarchy founded transformed itself into a system that indoctrinated students in the ideas of Confucianism and reverence for the Emperor. Footnote15 After the death of Okubo in 1878; Ito, Okuma, and Iwakura emerged as the three most powerful figures among the young bureaucrats that were running the government in the name of the Meiji Emperor. Iwakura one of the only figures in the ancient nobility to gain prominence among the Meiji oligarchy allied with Ito who feared Okuma's progressive ideas would destroy Japan's culture. Footnote16 Iwakura it is thought was able manipulate the young Emperor to grow concerned about the need to strengthen traditional morals. Thus in 1882 the Emperor issued the Yogaku Koyo, the forerunner of the Imperial Rescript on Education. Footnote17 This document put the emphasis of the Japanese education system on a moral education from 1882 onward. Previous to 1880 the Japanese education system was modeled on that of the French education system. After 1880 the Japanese briefly modeled their education system on the American system. Footnote18 However, starting with the Yogaku Koyo in 1882 and ending with the 1885 reorganization of the department of Education along Prussian lines the American model was abolished. The new education minister Mori Arinori after returning from Europe in 1885 with Ito was convinced that the Japanese education system had to have a spiritual oundation to it. Footnote19 In Prussia Arinori saw that foundation to be Christianity and he decreed that in Japan the Education system was to be based on reverence for the Imperial Institution. A picture of the Emperor was placed in every classroom, children read about the myths surrounding the Emperor in school, and they learned that the Emperor was the head of the giant family of Japan. Footnote20 By the time the Imperial Rescript on Education was decreed by the Emperor in 1889 the Japanese education system had already begun to transform itself into a system that did not teach how to think but instead what o think. The Imperial Rescript on Education in 1889 was according to Japanese scholars such as Hugh Borton , â€Å"the nerve axis of the new order. â€Å"Footnote21 Burton believes that the Imperial Rescript on Education signaled the rise of nationalistic elements in Japan. The Imperial Rescript on Education was the culmination of this whole movement to the right. The Rescript emphasized loyalty and filial piety, respect for the constitution and readiness to serve the government. It also exalted the Emperor as the coeval between heaven The Constitution of 1889 like the changes in the education ystem helped strengthen reverence for the Imperial Institution. The 1889 constitution was really the second document of its kind passed in Japan the first being the Imperial Oath of 1868 in which the Emperor laid out the structure and who was to head the new Meiji government. Footnote23 This Imperial Oath was refereed to as a constitution at the time but it only very vaguely laid out the structure of government. The constitution promulgated by the Emperor in 1889 did much more then lay out the structure of Japanese government it also affirmed that the Emperor was the supreme sovereign over Japan. Footnote24 The signing ceremony itself was an auspicious event on the way to it Mori Arinori one of the moderate leaders of the Meiji government was attacked and killed by a crazed rightist. Footnote25 The ceremony itself evoked both the past and present and was symbolic of the Meiji governments shift toward the right and the governments use of the Emperor as supreme ruler. Before signing the document Emperor Meiji prayed at the palace sanctuary to uphold the name of his imperial ancestors he then signed the constitution which affirmed the sanctity of the Emperor's title (Tenno Taiken), and his ight to make or abrogate any law. Footnote26 The constitution also set up a bicameral legislature. Footnote27 The constitution codified the power of the Emperor and helped the Meiji oligarchy justify their rule because they could point to the constitution and say that they were carrying out the will of the Emperor. The Meiji Emperor even after the Constitution of 1889 enjoyed little real power. The Meiji Emperor did not even come to cabinet meetings because his advisors told him if the cabinet made a decision that was different then the one he wanted then that would create dissension and would destroy the idea of the Imperial Institution. So even after the Meiji Constitution the Emperor was still predominantly a symbol. Footnote28 The Constitution ingrained in Japanese society the idea that the government was being run by higher forces who new better then the Japanese people, it also broadened the base of support of the Meiji Rulers who now had a document too prove they were acting on Imperial Will and their decisions were imperial decisions not those of mere mortals. Footnote29 The symbolism of the Emperor and use of Confucianism allowed the Meiji rulers to achieve their goals. One of their goals was the bolishment of the system of fiefs and return of all land to the Emperor. At first the new Meiji Rulers allied themselves with the Daimyo clans in opposition to the Tokugawa Shogun. But once the Meiji leaders had gained a control they saw that they would need to abolish the fief system and concentrate power in the hands of a central government. The Meiji rulers achieved their goals by having the Choshu, Satsuma, Tosa, and Hizen clans give up their lands, granting the Daimyos large pensions if they gave up their clans, and by having the Emperor issue two decrees in July 1869, and August 1871. Footnote30 The role and symbolism of the Emperor although not the sole factor in influencing the Daimyo to give up their fiefs, was vital. The Meiji Oligarchs said that not turning in the fiefs to the Emperor would be disloyal and pointed to the historical record which Meiji scholars claimed showed that historically all fiefs were the property of the Emperor. Footnote31 They showed this by claiming that the Shogun would switch the rulers of fiefs and this proved that the Daimyos did not control the title to their land but merely held it for the Emperor. Imperial decrees and slogans of loyalty to the Emperor also ccompanied the abolishment of the Samurai system. Footnote32 In the abolishment of both these feudal systems the symbolism of the Emperor as both the director of the initiative and recipient of the authority afterwards played a vital role in ensuring there success. Footnote33 The abolishment of fiefs and the samurai class were essential for the stability and industrialization of Japan. Footnote34 Without the concentration of land and power in the hands of the Meiji oligarchs and the Emperor the Meiji oligarchs feared they would receive opposition from powerful Daimyos and never gain control and uthority over all of Japan. Historical examples bear out the fears of the Meiji Oligarchy; in 1467 the Ashikaga Shogun failed to control many of the fiefs and because of this a civil war raged in Japan. Footnote35 The centralization of power allowed the Meiji government to have taxing authority over all of Japan and pursue national projects. Footnote36 The unity of Japan also allowed the Meiji Oligarchs to focus on national and not local issues. The use of Confucianism and the Emperor also brought a degree of stability to Japan during the tumultuous Meiji years. The Emperor's ere presence on a train or in western clothes were enough to convince the public of the safety or goodness of the Meiji oligarchy's industrial policy. In one famous instance the Japanese Emperor appeared in a train car and after that riding trains became a common place activity in Japan. The behavior of the Imperial family was also critical to adoption of western cultural practices. Before 1873 most Japanese women of a high social position would shave their eyebrows and blacken their teeth to appear beautiful. But on March 3rd 1873 the Empress appeared in public wearing her own eyebrows and with unblackened teeth. Following that day most women in Tokyo and around Japan stopped shaving their eyebrows and blackening their teeth. Footnote37 The Imperial institution provided both a key tool to change Japanese culture and feelings about industrialization and it provided stability to Japan which was critical to allowing industrialists to invest in factories and increase exports and The symbols and the traditions the Meiji leaders inculcated Japanese society with helped the Meiji government maintain stability and pursue its economic policies but it also had severe limitations that limited the revolutionary scope of the Japanese government and elped bring about the downfall of the Meiji era. The use of Confucianism and the Emperor to bolster the Imperial restoration laid the foundation for a paradox of state affairs. The system that sought to strengthen Japan through the use of modern technology and modern organization methods was using traditional values to further its goals. Footnote39 This caused some to turn toward the west for the â€Å"enlightenment† the Meiji era promised this was the case with Okuma who was eventually forced out of the increasing nationalist Genro. Footnote40 For others it lead them to severe nationalism rejecting all that was western. This was such the case of Saigo who believed till his death on his own sword that the Meiji leaders were hypocritical and were violating the Imperial Will by negotiating and trading with the west. Footnote41 The Meiji government used the same symbols and traditions that the Tokugawa used and like the Tokugawa gave the Emperor no decision making power. The Meiji Emperor although he had supreme power as accorded in the constitution never actually made decisions but was instead a pawn of the Meiji Genro who claimed to carry out his Imperial Will. This Imperial Will they decided for themselves. Like the Shogunate the Meiji governments claim to rule for the Emperor was fraught with problems. The Imperial Will was a fluid idea that could be adopted by different parties under changing circumstances. And just like the Meiji rulers were able to topple the Shogun by claiming successfully that they were the true administrators of the Imperial Will; the militarist elements in the 1930's were able to topple the democratic elements of Japan partially by claiming the mantle of ruling for the Emperor. Footnote42 From this perspective the Meiji Oligarchs building up of the Imperial Myth was a fatal flaw in he government. The constitution which says in article I, â€Å"The empire of Japan shall be governed over by a line of Emperors unbroken for ages eternal† gave to whoever was acting on the Imperial Will absolute The symbols of the Emperor and the tradition of Confucianism did not end with the end of the Meiji era or world war two. Today the idea of filial piety is still strong, multiple generations of a family still usually live together even in cramped Japanese housing. The religion of Shinto that the Meiji leaders rejuvenated during their rule in order to help foster the imperial cult is still thriving as he thousands of Tori gates and Shrines around Japan attest. Footnote44 But the most striking symbol to survive is that of the Emperor stripped after world war two of all power the Emperor of Japan is still revered. During the illness of Emperor Showa in 1989 every national newspaper and television show was full of reports related to the Emperor's health. During the six months the Showa Emperor was sick before he died all parades and public events were canceled in respect for the Emperor. Outside the gates of the Imperial palace in Tokyo long tables were set up where people lined up to sign cards to wish he Emperor a speedy recovery. The news media even kept the type of illness the emperor had a secret in deference to the Emperor. At his death after months of illness it was as if the Imperial Cult of the Meiji era had returned. Everything in Japan closed down , private television stations went as far as to not air any commercials on the day of his death. And now almost six years after his death more then four hundred and fifty thousand people trek annually to the isolated grave site of Emperor Showa. Footnote45 The traditions and symbolism of Confucianism and the Emperor ere critical to the Meiji oligarchs gaining control of power and goals of industrialization. The oligarchy inculcated the Japanese public with these traditional values through an education system that stressed moral learning, and through a constitution that established the law of Japan to be that of the Imperial Will. The values of Confucianism and symbol of the Emperor allowed the Meiji government to peaceful gain control of Japan by appealing to history and the restoration of the Emperor. But the Meiji oligarchs never restored the Emperor to a position of real political power. Instead he was used as tool by the oligarchs to achieve their modernization plans in Japan such as the abolishment of fiefs, the end of the samurai, the propagation of new cultural practices, and pubic acceptance of the Meiji oligarchs industrialization policies. The symbols and traditions of Japan's past are an enduring legacy that have manifested themselves in the Meiji Restoration and today in Japans continued reverence for Hidejiro Nagata, A Simplified Treatise on The Imperial House of Japan Takatsu Kuwasaburo, The History of The Empire of Japan (Tokyo: Dai Nippon Tosho Kabushiki Kwaisha, 1893) 206.